Got Myocarditis?

Spike, Toxin or Radiation Caused - Get NERF

NERF? Well, how about Nrf2 (Nuclear factor erythroid 2-related factor 2)? In earlier posts it was described how oxidative stress on cells (either from spike protein, EMF radiation or toxin) can cause dysregulation of miRNA (microRNA - Dicer & Drosha) which in-turn cause many forms of cellular disfunction. Specifically we need to understand the complexity of the Nrf2 system, which lies in the manner in which it is regulated in its expression, including miRNA influences, antioxidant protection, carcinogenesis protection, tumor suppression, cytoprotection of genes, glucose metabolism and dozens of other complicated cellular activities.

Specifically, dysregulated intracellular miRNAs result in the aggravation of myocarditis (below figure). Several dysregulated miRNAs are involved in the etiology and pathogenesis of myocarditis, show phase-dependent changes, and correlate with viral infection, immune status, fibrosis, destruction of cardiomyocytes, arrhythmias, cardiac functions, and outcomes.

“Researches have shown that a systemic Th1/Th2 imbalance exist during the clinical phase of myocarditis. Analysis of peripheral CD4+ T cells in a patient with acute myocarditis demonstrated that Th1 was dominant during the acute phase and coincided with increased serum levels of creatine kinase (CK), while Th2 predominated during the recovery phase and was accompanied by decreased CK levels. Consistent with this, restoring the Th1/Th2 inflammatory cytokine balance hindered the progression of autoimmune myocarditis” (link)

Basic summary: miRNA co-regulate the complex Nrf2 system that touches several systems. One of these dysregulations of miRNA through oxidative stress cause cardiomyocyte formation/destruction - myocarditis.

Natural Derivative Solutions

In order to re-regulate our Nrf2 systems, reduce risks and also undo cardiomyocyte degradation, we can utilize Heme-Oxygenase 1 Inducers. Simple right, just increase your Heme-Oxygenase 1 Inducers and you are set. (-_-)ゞ

Or…

Increase intake of the following naturally derived Nrf2 regulating solutions:

Circadian Cycle - NF-kB (inflammatory protein) - Good night’s sleep (dark room - no EMF)

Fulvic Acid, Humic Substances, Polyphenols - red wines & dark chocolate

Fatty Acids - nuts & fish

Quercetin - flavonoid commonly found in fruits and vegetables - red onion & tea leaves

Curcumin - polyphenolic root

Carnosic Acid and Carnosol - oxidative product (phenolic) - rosemary & salvia

Resveratrol - polyphenol present in many fruits and vegetables - grapes, cocoa, peanuts, berries & wine

Anthocyanins - flavonoid phenolic compounds - present in vegetables, flowers, and fruits such as berries

Epigallocatechin Gallate - polyphenol - EGCG - green tea

Phlorotannins - tannins - brown seaweed

Celastrol - quinone methide triterpene - root of the Thunder God Vine (Tripterygium wilfordii) and Celastrus regelii plant

Caffeic Acid Phenethyl Ester - antioxidant - honeybee propolis

Capsaicin - oleoresin - active ingredient of chili peppers

Garlic - derived organosulfur compounds - garlic (allium sativum) essential oil, mustard, asafoetida, and other food extracts

Isothiocyanates - antioxidant - cruciferous vegetables (broccoli etc.)

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Nrf2 & NF-kB - 2 proteins to know.

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“It was demonstrated in this article that high intakes of fruit and vegetables are associated with a decrease in cardiovascular diseases via endothelial protection. Thus the most important fruit/vegetables and bioactive compounds to prevent endothelial diseases are berries, apples, virgin olive oil, tomatoes, soybeans, and polyphenols, carotenoids and unsaturated fatty acids, respectively. The bioactive compounds from fruit and vegetables provide endothelial protection through the following mechanisms: improved eNOS/NO bioavailability, attenuates oxidative stress, inhibited NF-κB pathway and decreased cell adhesion molecules expression. In table SI (Supplementary Material) we show endothelial cell protection by natural bioactive compounds from fruit and vegetables.”