Digitizing and Converting Life to Binary

Hold Genome Transposon Mutagenesis with J. Craig Venter - The Endgame

Military science demi-god J. Craig Venter created life. He took a chemical and a computer-program-generated other chemical and created a new organism. Not sure why this was not the biggest news in the world, over a decade ago, but some of his other works include mapping the human genome (2000), creating the largest synthetic DNA structure (2008), mapping the genomes of thousands of organisms (on-going daily), [INSERT PUBLIC BIO BULLSHIT ad nauseum]. He created life, he created a virus out of software (sound familiar), he converted one species into another species, he has the genome of most mammals on earth. Enough said, or do we need to link to a bond-villain for direct comparison?

Military neurobiologist Dr. Charles Morgan discusses the significance of Venter’s work “Dr. Venter’s work is the equivalent of nuclear weapons… what he did was programmed yeast cells to produce anything he wanted. They can produce perfume, they can produce petroleum, they can produce any peptide, anything we program the DNA to do; and it’s in the living cell.”

“But you can engineer anything. You can engineer a unique thing that would only kill one person in the world.”

In the video clip below Venter himself describes the digitization process of converting genomes sequences to one’s and zero’s. It seems the only person that likes to hear his own voice more than Venter may be scientist-light and horse-genetic whisperer Robert Malone. But military-Malone, the dark vaccine wizard , has nothing on this bond villain.

In another lecture, Venter discusses his oh-so cavalier creation of biologic life in front of a NASA Ames crowd in 2010: “So we call a situation where the software is actually building its own hardware. All we did was put in a chemical piece of software and it led to making this physical structure that has biological activity.”

“But we didn’t want to make just a small virus, we wanted to make an entire bacterial chromosome…” Venter continues “transplanting a genome… is actually one of the most important ones (study) our team has ever published.”

From the study he discusses above - (Genome Transplantation in Bacteria: Changing One Species to Another):

“These data demonstrate the transplantation of whole genomes from one species to another such that the resulting progeny are the same species as the donor genome. However, they do not explain the mechanism of the transplant. This is not natural DNA transformation, where linear DNA enters the cytoplasm and recombines into the resident chromosome.”

“Because mycoplasmas are similar to mammalian cells with respect to their lack of a cell wall, we experimented with a series of approaches that are effective for transferring large DNA molecules into eukaryotic cells.”

“Our PEG-based method may be akin to PEG-driven cell fusion methods developed for eukaryotic cells… This basic approach of PEG-mediated genome transplantation may allow other species to be transplanted with naked genomes”

Summary: we can stuff a bunch of RNA and DNA in some lysosomotropic agents like PEGs or LNPs and the software in those RNA/DNA will transfect mammalian DNA and encode a new species into the genome, including the offspring of the mammal (aka human).

Continuing on in the same lecture, Venter goes onto to discuss his “Institute’s” and Clyde Hutchinson’s work in “hold genome transposon mutagenesis” as “small pieces of DNA that jump around in the genetic code. Over half of our human genome is composed of these transposons and they’re constantly jumping around. And if they jump into the middle of a key gene, we can get a disease or next generations won’t exist.”

From old Clyde’s work - Generating a synthetic genome by whole genome assembly: φX174 bacteriophage from synthetic oligonucleotides

“We have demonstrated the rapid, accurate synthesis of a large DNA molecule based only on its published genetic code. The accuracy of our final product was demonstrated by DNA sequencing and phage infectivity. Our methods will permit serial synthesis of gene cassettes containing four to seven genes in a highly robust manner.

There are many reasons to synthesize DNA chemically, rather than clone natural sequences, one of which is to prove correctness (or incorrectness) of a sequence, because many published sequences contain errors. The natural DNA may be unavailable to the experimenter for various reasons, including an uncooperative laboratory, an environmental sample that has been used up, an archaeological sample in short supply, or a sequence from badly degraded DNA or from an extinct organism. Also, the sequence could be deduced (rather than experimental) from an ancestral sequence, a designer protein, or a fusion of domains from different proteins.

There may be a hazard associated with the source of the natural sequence, or the target sequence may be RNA or a protein sequence rather than a DNA sequence. The sequence may need to be reengineered to alter the codon usage (or the code) for a particular host; to alter closely spaced regulatory signals or protein initiation (ribosome binding sites), promoters, or transcription terminators; to introduce restriction sites; or to allow convenient construction of a family of related (but different) constructs.

The combination of improved oligonucleotide synthesis combined with the methods described here will enable rapid, accurate synthesis of genomes of self-replicating organisms that will serve as a basis for understanding minimal cellular life. Synthetic genomics will become commonplace and will provide the potential for a vast array of new and complex chemistries altering our approaches to production of energy, pharmaceuticals, and textiles.”

Summary: we can create DNA software and infect/transfect it into mammal cells, that completes many operations to the genetics of these mammals, up to and including inserting transposons that can wipe out a whole species.

To what ends some may ask? Extinction of a species not enough of a modus operandi? How about big oil turning your cells into oil producing cells? You are going to have to earn your grazing, useless-eater, cow-like lifestyle somehow, says uncle Yuval. You can’t have any pudding unless you eat your Gatesmeat. How can you have any pudding unless you eat your Gatesmeat?

“SGVI is also announcing a three-year collaboration agreement with Novartis to apply synthetic genomics tools and technologies to accelerate the production of the influenza seed strains required for vaccine manufacturing. The seed strain is the starter culture of a virus, and is the base from which larger quantities of the vaccine virus can be grown. The agreement, supported by an award from the U.S. Biomedical Advanced Research and Development Authority (BARDA), could ultimately lead to a more effective response to seasonal and pandemic flu outbreaks.

Currently Novartis and other vaccines companies rely on the WHO to identify and distribute live reference viruses to create seasonal or pandemic vaccines. Under this collaboration, Novartis and SGVI will work to develop a ‘bank’ of synthetically constructed seed viruses ready to go into production as soon as WHO identifies the flu strains. The technology could reduce the vaccine production time by up to two months, which is particularly critical in the event of a pandemic.”

Big pharma, BARDA/DARPA, Big Tech, Big Oil… what could go wrong? This is how the spike protein bioweapon-vaccines were created: biological transportation.